Peyronie's · Published October 2026 · 11 min read

Non-Surgical Peyronie's Options in 2026: Xiaflex, Traction, and Filler Camouflage

For stable Peyronie's disease, the main non-surgical options are Xiaflex (collagenase) injections, penile traction, and — for mild-to-moderate curves — an ultrasound-mapped approach that releases scar bands and uses hyaluronic-acid filler to restore symmetry. In its pivotal trials, Xiaflex improved curvature by an average of about 34%. Traction studies typically report 20–30% reductions. Most oral supplements, including vitamin E, are recommended against by the American Urological Association. None of these reliably makes a curved penis perfectly straight. The right choice depends on the phase of the disease, the size and direction of the curve, and erectile function.

Below is a plain-English guide to each option: how it works, who it may suit, what it typically costs, and where it stops working.

Physician-reviewed · October 5, 2026

Active vs. stable phase: the first question

Peyronie's disease is scar tissue (a plaque) in the tunica albuginea, the sheath around the erectile chambers. The scarred side stretches less, so the erection bends toward it. Published estimates of how common it is vary widely, with some reviews reporting a prevalence of up to 9% of men.

The condition usually moves through two phases:

Active phase: the curve is changing, and erections may be painful. This typically lasts several months.
Stable phase: the curve has stopped changing and pain has usually settled. The AUA guideline describes stable disease as symptoms unchanged for at least three months; surgical guidance typically expects a longer stable window before reconstruction.

Phase matters because most corrective treatments — including filler — are designed for a curve that has stopped moving. Correcting a moving target is how people end up needing a second correction.

Xiaflex (collagenase): the FDA-approved injection

Xiaflex is collagenase Clostridium histolyticum, an enzyme injected directly into the plaque to break down some of the collagen that causes the bend. It is the only drug FDA-approved for Peyronie's, indicated for adult men with a palpable plaque and a curve of at least 30 degrees.

How it's given: each cycle is two injections a few days apart followed by penile "modeling" (gentle manual stretching) by the clinician, with home modeling between visits. The label allows up to four cycles, spaced about six weeks apart.
What results look like: across the two pivotal IMPRESS trials, men treated with Xiaflex averaged about a 34% improvement in curvature (roughly 17 degrees), compared with about 18% on placebo. A 60-degree curve might become something closer to 40 degrees. Meaningful, rarely straight.
Who it suits: the AUA supports it for stable disease with a curve between 30 and 90 degrees and intact erectile function (with or without medication). The trials excluded ventral (downward) curves, isolated hourglass deformities, and calcified plaques.
Main risks: bruising, swelling, and pain are common. The serious one is corporal rupture (penile fracture), which the AUA says every patient should be counseled on before starting.
Cost: the listed price is about $6,950 per vial, and each cycle uses two vials, so a full four-cycle course can exceed $50,000 before insurance. The manufacturer says most eligible commercially insured patients pay $0 out of pocket. Coverage varies; check with your plan.

Xiaflex does not add girth. For men whose primary concern is size, it addresses a different problem.

Traction devices

Penile traction therapy uses a device that holds the penis under gentle, sustained stretch. The idea is the same one orthodontics uses: steady tension remodels tissue over time.

Evidence: a 2025 review of modern devices reported mean curvature reductions of 20–30% and length gains averaging 1.5–2.3 cm, with some newer protocols using 30–90 minutes a day. Older devices required four or more hours daily.
As an add-on: the same review reports that adding traction to Xiaflex improved curvature correction by an additional 5–10%.
The honest caveat: the AUA notes that traction studies have been small and need confirmation in larger randomized trials. Results depend almost entirely on sticking with it for months.
Cost: devices are typically a few hundred dollars and are rarely covered by insurance.

Traction is low-risk and worth discussing with a urologist, especially if length loss is part of the concern.

Oral, topical, and other injections

This is where most of the internet's advice lives, and where most of it falls apart.

Supplements: the AUA says clinicians should not offer oral vitamin E, tamoxifen, procarbazine, omega-3 fatty acids, or vitamin E with L-carnitine for Peyronie's.
Anti-inflammatories: NSAIDs may be offered for pain during the active phase. They manage symptoms; they don't straighten anything.
Other plaque injections: intralesional interferon alpha-2b and verapamil are used by some urologists, with more modest and less consistent evidence than Xiaflex. Hyaluronic acid injected into the plaque has also been studied in Europe, mainly in small single-center series.

If a website is selling a cream or a pill as a Peyronie's cure, that tells you more about the website than the condition.

The WIDR approach: map the scar, release it, support healing, then fill

This is the option WIDR offers, so here is the full picture, including where it doesn't fit.

A Peyronie's curve is an asymmetry: scar tissue makes one side effectively shorter than the other. Filler alone can only disguise that. WIDR's approach addresses the scarring first, in the same session as the girth treatment.

1. See the scarring on ultrasound

Before anything is placed, the WIDR physician scans with handheld ultrasound. Ultrasound shows what a physical exam can't: where the plaque and scar bands sit, how large they are, and how they relate to the tissue planes and blood vessels. That map decides the plan. It is also how the physician may tell you, before anything is done, that a curve is outside what this approach can help.

2. Release visible scar bands (subcision)

Where scarring beneath the skin is tethering tissue and contributing to the pull, the physician may release those bands with a blunt cannula. This technique is called subcision. It is a well-established technique in aesthetic medicine, used for scars elsewhere on the body.

3. Support healing with the Placental Protein Matrix

WIDR's filler is blended with a proprietary Placental Protein Matrix, which is intended to support tissue healing after the release, with the aim of less new scarring as the area recovers.

4. Fill to restore symmetry and keep the tissue from re-adhering

Hyaluronic-acid filler is then placed where it's needed. It does two jobs:

Symmetry: volume on the concave (shorter) side may reduce how pronounced the bend looks, while adding circumference.
A spacer: filler in the released space helps keep the tissue from scarring back down to itself as it heals.

The physician scans again with ultrasound afterward to confirm placement. The method page explains the technique in detail.

Because it is HA, the result is adjustable and reversible. If the balance isn't right, it can be refined or dissolved with hyaluronidase. That matters in a condition that can change over time.

Where this approach may help

Mild-to-moderate curves in stable disease.
Men who also want added girth — both concerns in one treatment.
Men who want a reversible, non-surgical option first.

Where it is the wrong tool

Active disease. If the curve is still changing, wait.
Severe or complex curves — large angles, hourglass or hinge deformities, or curves that make intercourse difficult.
Erectile dysfunction that limits rigidity. This approach doesn't treat ED.
Men expecting a straight penis. The goal is a less visible bend and better symmetry. It does not straighten the erectile chambers, and no result is guaranteed.

Treatment is priced by syringe count on the same published WIDR pricing used for girth enhancement: Essential $3,500 (up to 4 syringes), Signature $5,900 (5–8), Complete $7,900 (9–12). More on candidacy is on the Peyronie's page.

Side-by-side comparison

Option	Typical effect on curve	Adds girth?	Reversible?	Typical cost
Xiaflex Up to 4 cycles over ~6 months	~34% average improvement in trials	No	No (changes the plaque)	Often covered; ~$6,950/vial list
Traction Daily use for 3–6 months	~20–30% in reviews; adherence-dependent	No (may help length)	Yes (non-invasive)	A few hundred dollars
Oral supplements	Not supported by AUA	No	—	Varies
WIDR: scar release + HA filler 1–3 sessions	May reduce visible bend and improve symmetry in mild-to-moderate curves	Yes	Yes (hyaluronidase)	WIDR: $3,500–$7,900 per session
Surgery	Designed to straighten	No (plication may shorten)	No	Varies widely; may be covered

These options aren't mutually exclusive. Some men do Xiaflex or traction first and consider filler later for residual curvature and girth, once things are stable.

When surgery is the right answer

Surgery is the most definitive way to straighten a Peyronie's curve, and for some men it is the correct first choice rather than a last resort. Guidance generally reserves it for disease that has been stable and painless for a sustained period, when the deformity makes intercourse difficult.

Plication: sutures on the longer side to even out the curve. Effective, but can cost some length.
Plaque incision or excision with grafting: for larger or complex curves; preserves more length with higher surgical complexity.
Penile prosthesis: for men with Peyronie's and significant erectile dysfunction, often combined with modeling.

If your curve is severe, complex, or interfering with sex, the right next step is a urologist who specializes in Peyronie's. During a WIDR consultation, the WIDR physician will tell you plainly if that's your situation.

Frequently asked questions

Can Peyronie's disease be treated without surgery?

Often, yes, for mild-to-moderate stable disease. Xiaflex injections, traction therapy, and ultrasound-mapped scar release with hyaluronic-acid filler are the main non-surgical options. They typically reduce curvature or its appearance rather than eliminate it. Severe or complex curves are more often treated surgically.

How much does Xiaflex improve curvature?

In its pivotal trials, Xiaflex improved curvature by an average of about 34% (roughly 17 degrees), compared with about 18% on placebo. Individual results vary.

Does filler straighten a Peyronie's curve?

Not on its own, and no result is guaranteed. At WIDR, ultrasound is used first to see the scarring, visible scar bands may be released (subcision), and hyaluronic-acid filler is then placed to improve symmetry and help keep the released tissue from scarring back down. The goal is a less visible bend plus added girth in mild-to-moderate stable curves. It does not straighten the erectile chambers.

What is subcision, and why is it used for Peyronie's?

Subcision is the release of scar bands beneath the skin with a blunt cannula, a technique long used for scars elsewhere on the body. At WIDR, where ultrasound shows scarring tethering the tissue, the physician may release it, then place filler in the space so the tissue is less likely to re-adhere as it heals.

What does the Placental Protein Matrix do?

WIDR blends its hyaluronic-acid filler with a proprietary Placental Protein Matrix, intended to support tissue healing after treatment with the aim of less new scarring. Your physician will explain what it is and what to expect at your consultation.

Can I get filler during the active phase?

Generally, no. While the curve is still changing, any correction is aimed at a moving target. Most men are advised to wait until the curve has stopped changing and pain has settled.

Do vitamin E or supplements work for Peyronie's?

The American Urological Association recommends against oral vitamin E, tamoxifen, procarbazine, omega-3 fatty acids, and vitamin E with L-carnitine for Peyronie's disease.

Can I combine Xiaflex or traction with filler?

Potentially, in sequence. Some men use Xiaflex or traction first, then consider filler once the disease is stable for residual curvature and girth. Timing is a conversation for your consultation and your urologist.

What does Peyronie's filler cost at WIDR?

The same published tiers used for girth enhancement: Essential $3,500 (up to 4 syringes), Signature $5,900 (5–8 syringes), Complete $7,900 (9–12 syringes). Pricing is by syringe count, not by diagnosis. See full WIDR pricing.

Sources

Not sure which option fits your curve? Start a free email consultation — a free exchange by email with Kevin, WIDR's owner. The physician determines the assessment needed for a treatment plan. You'll get a straight answer on candidacy, including when filler is not the right tool. See how WIDR approaches Peyronie's and published pricing.